Efficacy Study of Dolichos biflorus in the Management of Nephrotoxicity

نویسندگان

  • Sarmistha Saha
  • Ramtej J Verma
چکیده

Ethylene glycol is an intermediate in the synthesis of a number of commercial chemical products, including polyethylene terephthalate resins, unsaturated polyester resins and polyester fibers and films. It is also a constituent in antifreeze, deicing fluids, surface coatings, heat transfer fluids, industrial coolants, hydraulic fluids, surfactants and emulsifiers[1]. General population, or consumer, exposure occurs primarily from the use of ethylene glycol in automotive antifreeze. There have been a number of acute human poisonings from accidental or intentional ingestion of antifreeze, with the kidney being the most sensitive target organ. Plants are known to provide a source of inspiration for novel drug compounds and this is sequel to the fact that medicines derived from plants have made large contributions to human health and well being. Dolichos biflorus L. is a genus of family Fabaceae, a leguminous edible pulse crop of the subtropics, commonly known as Kulthi in the Indian Systems of Medicine and is a branched or trailing annual, with small trifoliate leaves, and very wide climbing, slender stem. When it matures, it gives narrow, flat and curved pods. The pods contain 5-6 flattened ellipsoid seeds. Traditionally its seeds are used in traditional formulations for the treatment of leucorrhoea, menstrual troubles and ulcer. In Unani medicine, the concentrated water extract of kulthi seeds and shalgram (Brassica rapa) seeds are given for destroying stones in the kidney. The aqueous extracts of seeds of D. biflorus inhibited homogenous precipitation of calcium hydrogen phosphate dihydrate crystals[2]. However, the effects of these extracts have not been evaluated in animal models. The seeds of D. biflorus have been reported to show anti-hepatotoxic[3], anti-nephrotoxic[4], free radical scavenging activity[5,6], antioxidant[7,8] and hypolipidemic[9] activity. Soup prepared from seeds is beneficial in enlarged liver and spleen. Analysis of seeds showing moisture 11.8%, crude protein 22.0%, fat 0.5%, mineral matter 3.1%, fibre 5.3%, carbohydrate 57.35%, calcium 0.28% and phosphorous 0.39%; iron 7.6mg, nicotinic acid 1.5 mg, carotene 119 (international vitamin unit A unit) per 100 g and rich in various enzymes. ARTICLE INFO ABSTRACT

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تاریخ انتشار 2012